Nationwide survey of Lambert-Eaton myasthenic syndrome in Japan

Background There was no nationwide epidemiological study of Lambert-Eaton myasthenic syndrome (LEMS) in Japan; therefore, we conducted a nationwide survey.Methods For the first survey, we sent survey sheets to randomly selected medical departments (n=7545) to obtain the number of LEMS who visited medical departments between 1 January 2017 and 31 De

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Design of mine-used digital broadcasting rescue guide system

In order to solve the problem of communication information blockade during disaster rescue in coal mines underground, a new type of mine-used digital broadcasting rescue guide system was developed.The key technologies, main devices and characteristics of the Foil system were introduced.The system uses technologies of IP network communication, multi

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The value of machine learning for prognosis prediction of diphenhydramine exposure: National analysis of 50,000 patients in the United States

Background: Diphenhydramine (DPH) is an antihistamine medication that in overdose can result in anticholinergic symptoms and serious complications, including arrhythmia and coma.We aimed to compare the value of various machine learning (ML) models, including light gradient boosting machine (LGBM), logistic regression (LR), and random forest (RF), i

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The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping

Summary: Glioblastoma stem-like cells (GSCs) compose a tumor-initiating and -propagating population remarkably vulnerable to variation in the stability and integrity of the lysosomal compartment.Previous work has shown that the expression and activity of the paracaspase MALT1 control GSC viability via lysosome abundance.However, the underlying mech

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Conduction band offset-dependent induced threshold voltage shifts in a-InGaZnO TFTs under positive bias illumination stress

In this paper, the dependence of threshold voltage (Vth) changes to amorphous-indium gallium zinc oxide (a-IGZO) thin film transistors (TFTs) under positive bias light illumination (PBIS) on the height Gravel of the conduction band offset was studied.Using SiO2, HfO2, and Al2O3 as gate dielectrics, three different types of a-IGZO TFTs were used in

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